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Peak plasma concentrations are generally observed 2 to 3 hours after ingestion. Peak plasma concentrations are generally observed 2 to 3 hours after ingestion. Of the complications of baclofen paralysis, contractures that develop quite early due to muscle imbalance are in the first place. Of the complications of baclofen paralysis, contractures that develop quite early due to muscle imbalance are in the first place. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. To avoid the risk of baclofen overdose, always take the medication as directed. To avoid the risk of baclofen overdose, always take the medication as directed. Baclofen is also available as an intrathecal solution, which means it’s injected into the spinal cord by a special pump. 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