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Renal failure, Cardiovascular collapse, Diabetic ketoacidosis, Severe hepatic insufficiency, Severe impairment of thyroid function, Severe infection or shock. Characterized by higher-than-normal levels of blood glucose, T2DM is a complex disorder that arises from the interaction between genetic, environmental and behavioral risk factors Glucotrol Mf Tablet works by the combined action of Glipizide and Metformin. 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